Background and objectives: Non-invasive ventilation (NIV) has been evaluated in a large number of trials, often with clinically important benefits, but its use remains highly variable across institutions. Hence, in the present study, we aimed to identify the factors that predict the success and outcome of non-invasive ventilation in acute exacerbation of COPD. Methods: This was a prospective observational study of 150 adult patients admitted with AECOPD. Demographic information such as Age, Sex, history of smoking, etc. and clinical parameters like Respiratory Rate, Heart Rate, blood pressure, and Arterial Blood Gas variables like pH, PaO2, PaCO2, HCO3, and SaO2 were measured at just before NIV, at 6thhr and 18th hr after the start of NIV. The outcome was recorded as success and failure with NIV. Results: Respiratory Rate was lower and showed significant improvement at 6th hr in subjects who successfully improved with NIV. Oxygen saturation was found to be significantly higher among subjects successfully managed with NIV at 18th hr (90.35 ± 3.391 vs 82.00 ± 2.828) as compared to patients who required intubation. pH was found to be higher (7.47 ± 0.05 vs 7.27 ± 0.27) and PaCO2 levels were lower before NIV and significant improvement in pH and PaCO2 at 6th hr and 18th hr respectively was observed in NIV success patients. Out of 150 patients, 132 (88%) managed successfully with NIV and in 18 subjects (12%) NIV failed. Among NIVfailure subjects, 5 died and 13 subjects were intubated, out of which, 11 were discharged, and 2 subjects died. Conclusion: In the present study, low BMI, improvement in parameters like heart rate, respiratory rate, PaO2, PaCO2, pH, SaO2 and HCO3 at 6th hr of NIV are the factors predicting the success and outcome of NIV among AECOPD patients.