Aim: To analyse the utility of RBC histogram interpretations in assessing red blood cell disorders. Material and Methods: A cross-sectional study to evaluate the utility of automated complete blood count parameters in various haematological disorders was undertaken. Red blood cell indices like MCV, MCH, MCHC, RDW-SD and RBC histogram interpretations were helpful in making the diagnosis on peripheral blood smear examination. The study consisted of 500 cases which were examined using histogram and peripheral smear examination. Results: The predominant age group affected was 20–30 years. Peripheral smear finding shows normocytic normochromic anemia was seen in 47.2% cases, microcytic hypochromic anemia seen in 40% cases, macrocytic anemia seen in 10.8% cases and dimorphic anemia seen in 2% cases. 52.8% of cases had normal shift in histogram curves. This peripheral smear finding shows well correlation with findings of histogram pattern and RBC indices. Conclusion: Histogram guides a technologist about the cases that need actual detailed peripheral smear examination by experts. It could be used as screening method and when combined with peripheral blood smear findings, they act as useful supplement and by correlating findings of both methods, we could diagnose majority of anemia.