Background: The advantages of laparoscopic procedure are lesser postoperative pain, lesser incidence of surgical site infection and shorter hospital stay. The present study was conducted to compare three port laparoscopic cholecystectomy with four port laparoscopic cholecystectomy.Materials&Methods: The study comprised of 120 patients which were randomly taken for a three port (Group 1,60 patients) or four port laparoscopic cholecystectomy (Group 2, 60 patients). Our primary outcome measure was pain score and analgesia requirement after surgery. Statistical analysis SPSS was used for statistical analysis. Student-test was used to evaluate the significance of each parameter. P value< 0.05 was considered statistically significant.Results: Operative times were similar between the two groups (P=0.1079). Intra-operative complications were same in no. in both groups (P=1.00). Post-operative pain score on VAS in three port group was 2.32±1.12 and in four port group was 2.88±1.19 (p=0.259*). The amount of analgesia in the early postoperative period was significantly higher in Group 2.There was also statistically significant difference in the number of oral analgesic tablets consumed by the patients after they were discharged from hospital. Mean postoperative stay was not statistically significant. Days to return to normal activity in 3 port group and four port was not statistically significant. There was no significant difference between the two groups regarding the mean patient satisfaction score for the scar on day 7.Conclusion: The present study concluded that the three-port technique is as safe as the standard four-port technique with an advantage of less pain and less analgesic requirement and better cosmetic results.