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Volume 12 Issue 1 (January- March) 2023

Original Articles

To study the correlationship of proteinuria with blood pressure in patients with diabetic nephropathy
Dr. Bharat Batham, Dr. Shubham Upadhyay, Dr. Satyam S. Jayant, Dr. Pankaj Kumar Gupta

Background: Diabetic nephropathy develops in one third of the patients with diabetes. The incidence is increasing worldwide and the Asia pacific region being the most affected . According to statistical prediction, in India diabetic nephropathy is expected to develop in 6.6million people out of 30million people with diabetes. Studies in south India have shown that the prevalence of microalbuminuria is 26.9% and overt proteinuria is 2.2%.Prevalence of diabetic nephropathy in Asia in Vellore (India) was 8.9%, and Asians in Leicester, United Kingdom was 22.3% and Caucasians in Leicester, in United Kingdom was 12.6%. Method: The aim of the study is to study the correlationship of proteinuria with blood pressure in patients with diabetic nephropathy. Patients with diabetes mellitus and eGFR <90 ml/min/1.73 m2 were included in the study. Clinical profile of each patient was noted and 24hrs urine protein was estimated. Blood samples were sent to estimate blood sugar, lipid profile, HbA1c and serum creatinine. Result: The mean duration of diabetes in our study is 9 years 4 months and mean SBP is 146 mm Hg and DBP is 92 mm Hg. As the duration of diabetes increases, hypertension prevalence also increases and is maximum in diabetes of >10 years duration (45.45%). The present study showed that 15.9% of diabetics of duration >10 years were found to have eGFR <15 ml/min/1.73 m2 as compared to nil patients in those with diabetes duration of upto 5 years. Among the 40diabetics who had hypertension, 26(65%) patients had proteinuria >1 gm/day. 82.3% patients patients with SBP ≥180 and/or DBP ≥110 mm Hg showed urinary protein >1 gm/day as compared to 40% patients with SBP 140-159 and/or DBP 90-99 mm Hg. The present study also shows, proteinuria increases as the duration of diabetes increases. Conclusion: Our study has shown a positive correlation between raised blood pressure levels and proteinuria in patients of diabetic nephropathy. 24 Hr urinary protein were high in patients with higher blood pressure and duration of diabetes >10 years.

 
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