Background Recurrent hiccups are a challenging condition with limited effective treatment options. Baclofen, a GABA agonist used for spasticity, has been studied as a potential treatment for recurrent hiccups. This review evaluates current evidence for the use of baclofen in the treatment of recurrent hiccups. Methods We present a case series of 5patients along with a literature review affected by recurrent and chronic hiccups which was successfully treated with baclofen. Results Hiccups stopped in all patients after the administration of a short course of baclofen. While the optimal dosage is not well established, starting doses of 5 to 10 mg three times a day with gradual titration to a maximum of 30 to 40 mg per day were found to be effective. Conclusions Despite numerous available options, recurrent hiccups remain an enigma in terms of response to treatment. We observed a fast and adequate response on baclofen where other modalities failed or were ineffective. Baclofen may be a valuable addition to the treatments for recurrent hiccups, but further research is needed to determine the optimal dosage, duration, and safety of baclofen for the treatment of hiccups.