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Genetics of Stroke: Review

Khalil Hamzi1, Brehima Diakite2, and Sellama Nadifi3
1 Laboratoire de Genetique et pathologie moleculaire- Faculty de medecine et de pharmacie-University hassan II Casablanca- Morocco.
2 Laboratory of Genetics and Molecular Pathology, Faculty of Medicine and Pharmacy, University Hassan II Casablanca-Morocco.
3 Laboratoire de G¨¦n¨¦tique et pathologie moleculaire, Laboratory of Genetics and Molecular Pathology.
Abstract—Cerebral Vascular Accident (stroke), despite remarkable progress within recent years in the field of its management and treatment, remains a major cause of mortality and morbidity in many countries. Genetics of complex diseases has known a great progress in recent years , due to technology development, but also to two major international initiatives; the Human Genome Project that has enabled the sequencing of the human genome in its entirety and the discovery of SNP (Single Nucleotide Polymorphisms), which had a great success for association studies. Genetic studies of stroke have shown that apart from rare forms with Mendelian transmission, most strokes are considered as multi-factorial disease. The genetic study of stroke is being more and more research¡ªmore than 2300 candidates for stroke polymorphisms are currently listed. These factors have generally been short-listed based on their involvement in metabolic pathways known or through studies pangenomics. The most of them have been association studies by different teams and different populations. Although most of these studies seem to focus more on myocardial infarction stroke is attracting increasing interest of researchers. The genes studied are most typically those involved in the coagulation pathway, the metabolism of homocysteine, and lipid metabolism namely FV, FII, fibrinogen, PAI1, MTHFR, ApoE and ACE. Others have been explored without consensus (Enos, PON, LPL, FGA / FGB / FGG, F7, F13A1, vWF, F12, SERPINE1, ITGB3, PLA2, ITGA2B, ITGA2, GP1BA, AGT, NOS3, LPL, PON1, PDE4D, ALOX5AP, MTR, CBS, NINJ2). The results published today are often controversial depending on the population studied, age of patients and subtypes of stroke. Some of these factors come close to the consensus than others.

Index Terms—Stroke, Genetics, GWAS

Cite: Khalil Hamzi, Brehima Diakite, and Sellama Nadifi, "Genetics of Stroke: Review," International Journal of Life Sciences Biotechnology and Pharma Research, Vol. 1, No. 1, pp. 1-15, January 2012.
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