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Medicated Lollipops for the Treatment of Oral Thrush in Children

Purushotham Rao K1, Shivappa N Nagoba2, Vishwanath Reddy1, Ayshiya S A3, Zakaullah S3, Ashok Kumar C4, Anand C4, and Saran S V1
1 HKE¡¯s College of Pharmacy, Gulbarga, Karnataka, India.
2 Karpagam University, Coimbatore, Tamilnadu, India.
3 Al-Badur Rural Dental College & Hospital, Gulbarga, Karnataka, India.
4 Rural Medical College and General Hospital, Loni (MS), India.
Abstract—Oral thrush is a disorder caused by infection of the mouth due to fungus (yeast) Candida albicans. In babies it may be a severe infection sometimes causing epidemics in schools by cross infection. The "lozenges are flavored medicated dosage forms intended to be sucked and hold in the mouth/pharynx. These preparations are commonly used for the purpose of local effect or systemic effect". Advantages of the lozenges as dosage forms include increase in bioavailability, reduction in gastric irritation, bypass of first pass metabolism and increase in onset of action. New drug design to this area always benefit for the patient, physician and drug industry. In the present investigation an attempt has been made to prepare and evaluate medicated lollipops of Ketoconazole. The lollipops were prepared by heating and congealing method in a candy based industry with sucrose base. All the formulations prepared were subjected to various physico- chemical parameters like hardness, content uniformity, friability, weight variation etc. The prepared formulations have a hardness of 10-12 Kg./cm2, with good taste. Stability studies of selected formulations were carried out at 37oC for a period of six months. Selected formulations were tested for drug excipient interactions subjecting to IR Spectral analysis. In-vitro drug dissolution studies showed 95.35% for K1 and 73.24% for K2 release of drug in 30 minutes, 99.43% in 7 minutes from K0 formulation. The prepares lozenges were subjected for anti microbial studies by agar cup plate method using the organisms collected from a diseased pediatric patient under the supervision of dental physicians and with the permission of ethical committee. The prepared lollipops were also subjected for preclinical studies to find out oral compatibility in healthy human volunteers. The tablet lozenges can provide an attractive alternative formulation in the treatment of oral thrush in pediatric patients.

Index Terms—Ketoconazole, Lollipops, Oral thrush.

Cite: Purushotham Rao K, Shivappa N Nagoba, Vishwanath Reddy, Ayshiya S A, Zakaullah S, Ashok Kumar C, Anand C, and Saran S V, "Medicated Lollipops for the Treatment of Oral Thrush in Children," International Journal of Life Sciences Biotechnology and Pharma Research, Vol. 1, No. 1, pp. 95-102, January 2012.
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