HCV Infection and its Association with HLA Alleles - Volume 1, No.2, April, 2012 - IJLBPR
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HCV Infection and its Association with HLA Alleles

A Shankarkumar and U Shankarkumar
National Institute of Immunohaemtology, 13 Floor, KEM Hospital. Parel, Mumbai - 400012, Maharashtra, India.
Abstract—Host genetic diversity is believed to contribute to the spectrum of clinical outcomes in hepatitis C virus (HCV) infection. The frequencies of HLA class I and class II alleles of HCV infected were reviewed and analyzed with literature available from published literature. The analysis showed that he associations of HLA-A*02 and HLA-DRB1*12 with HCV infection are opposite with different races. HLA-A*03, Cw*05, DRB1*01, DQB1*03 and DQB1*05 are associated with viral clearance while HLA-DRB1*07 and DQB1*02 are risk markers for viral persistence of HCV infection in Midwestern Americans. These results reveal ethnically and geographically different distribution of HLA-genes which are associated with the outcome of HCV infection.

Index Terms—HCV, HLA, association

Cite: A Shankarkumar and U Shankarkumar, "HCV Infection and its Association with HLA Alleles," International Journal of Life Sciences Biotechnology and Pharma Research, Vol. 1, No. 2, pp. 10-19, April 2012.
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