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Analgesic Activity of the Fruit Extract of Averrhoa Carambola

Biswa Nath Das1 and Muniruddin Ahmed2
1. Department of Pharmacy, Noakhali Science and Technology University, Noakhali, Bangladesh
2. Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Bangladesh
Abstract—This experimental study was done to investigate analgesic activity of fruit extract of Averrhoa carambola in Swiss-Albino mice. Analgesic activity was assessed by acetic acid-induced writhing method (for peripheral action) and radiant heat tail-flick test (for central action). For both tests, healthy Swiss-Albino mice of either sex weighing 20-25 g were used for the test; twenty-four mice, aged 4-5 weeks, were randomly selected and divided into four groups with six animals in each group. Each group was given a particular treatment i.e. control, positive control and the two different doses of the extract. In the acetic acid-induced writhing test, the extract in doses of 200 and 400mg/kg showed 37.13% (p<0.001) and 42.76% (p<0.001) inhibition of writhing respectively. In radiant heat tail-flick method the crude extract produced 33.65% and 40.88% elongation of tail flicking time 60 minutes after oral doses of 200 and 400 mg/kg body weight respectively. 

Index Terms—averrhoa carambola, analgesic activity, acetic acid-induced writhing test, radiantheat tail-flick method

Cite: Biswa Nath Das and Muniruddin Ahmed, "Analgesic Activity of the Fruit Extract of Averrhoa Carambola," International Journal of Life Sciences Biotechnology and Pharma Research, Vol. 1, No. 3, pp. 22-26, July 2012.
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