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Arsenic-Induced Histological Alterations in Various Organs in Rats

P. Hemalatha1, A. Anandkumar1, A. Gopala Reddy 1, M. Usha Rani 2, and P. Shivakumar1
1. Department of Pharmacology & Toxicology, Rajendranagar, Hyderabad 500030, India.
2. Department of Pathology, College of Veterinary Science, Rajendranagar, Hyderabad 500030, India.
Abstract—In the present study, effect of N-acetyl cysteine was evaluated against arsenic-induced histological alterations in rats. The Wistar rats were divided into 4 groups and treated as follows: Group 1: sham control, 2: arsenic control (sodium arsenite @ 10 mg/kg b. wt orally for 4 wks), 3: Pre- treatment with NAC (@ 300 mg/kg orally for 2 wks) followed by sodium arsenite along with NAC (as per above doses) and 4: Sodium arsenite + NAC (as per above doses for 4 wks). Group 2 (arsenic control) showed marked degenerative changes in heart, kidney, liver, testis, lung, intestine and stomach. Group 1 did not reveal any abnormalities on histopathology. NAC-treated groups (3 and 4) showed improvement in all the parameters studied, though it was marked with NAC pre-treatment.

Index Terms—Arsenic, Histopathology, NAC

Cite: P. Hemalatha, A. Gopala Reddy, M. Usha Rani, A. Anandkumar, and P. Shivakumar, "Arsenic-Induced Histological Alterations in Various Organs in Rats," International Journal of Life Sciences Biotechnology and Pharma Research, Vol. 2, No. 1, pp. 119-127, January 2013.
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