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Effect of Individual and Combination of Herbal Extracts on Glucose Tolerance, in Euglycemic Rats

Mathada V. Ravishankar and Praful S. Jevoor
Department of Anatomy, J.N. Medical College, K.L.E. University, Belgaum- 590010, Karnataka, India.
Abstract—Objective: To assess the glucose tolerance of alcoholic plant root extract of Clitoria ternatea Linn and Salacia chinensis Wight, individually and in combination. Methods : The 20 wistar rats each weighing around 150g were randomly divided in to 4 groups, each group containing 5 rats. Normal control group was fed with 2g/kg body weight glucose alone and treatment groups were administered with 100mg/kg body weight extract of Clitoria ternatea Linn and Salacia chinensis Wight separately and in combination, all these administrations were done orally by using oral gastric tube which is followed by the administration of 2 g/kg body weight of sugar. Later blood sugar was measured after every 30min till the end of 90 min duration. The results were summarized by mean +/- standard deviation of blood sugar levels at regular intervals of time, one way Analysis of variance (ANOVA) was used to compare the mean blood sugar level of 4 groups which is followed by Schiff¡¯s multiple comparison test. Results: Both the drugs have shown increased glucose tolerance, but when they were administered in combination the results have shown increased tolerance of glucose in rats at the end of 90 min when compared with the extracts administered individually. Conclusion: Theherbs Clitoria ternatea Linn and Salacia chinensis Wight have the capacity to increase the glucose tolerance but their combined administration is showing relatively a higher degree of tolerance against their administration individually, this effect could be due to cellular level interaction of number of phytochemicals to increase the post prandial glucose tolerance.

Index Terms—Herbal extracts, Glucose tolerance, Clitoria ternatea Linn, Salacia chinensis Wight, Euglycemia, Prediabetic, Streptozotocin.

Cite: Mathada V. Ravishankar and Praful S. Jevoor, "Effect of Individual and Combination of Herbal Extracts on Glucose Tolerance, in Euglycemic Rats," International Journal of Life Sciences Biotechnology and Pharma Research, Vol. 2, No. 1, pp. 217-224, January 2013.
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