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The Effect of Vitamin-C Therapy on Hyperglycemia, Hyperlipidemia and Non High Density Lipoprotein Level in Type 2 Diabetes

Shreyasi Vaksh1, Mukesh Pandey 1, U. S. Zingade 2, and Varikasuvu Seshadri Reddy 3
1. Department of Physiology, Hi-tech Medical College & Hospital, Rourkela-769004, Odisha, India.
2. Govt. Medical College, Aurangabad, India.
3. Department of Biochemistry, Hi-tech Medical College & Hospital, Rourkela-769004, Odisha, India. ¡ì: equally contributed.
Abstract—India is standing top in the prevalence of type 2 diabetes mellitus. Hyperglycemia and hyperlipidemia are important factors that develop diabetes associated complications. Vitamin C is known for its beneficial effects on serum lipids. Therefore, we evaluated the effects of Vit-C supplementation (1g/day) for four week duration among 30 patients by measuring fasting blood sugar (FBS), serum levels of total cholesterol (TC), triglycerides (TG), reduced high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C) and non-HDL-C (nHDL-C). The results obtained were compared with baseline values and with 30 age and sex matched controls. The differences between male and female patients were also studied. Patient group had hyperlipidemia compared to control group. Upon Vit-C therapy, patients showed a significant decrease in FBS, TC, LDL-C and nHDL-C versus baseline values before treatment. Female patients had higher levels of TC and nHDL-C compared to male patients, both before and following Vit-C supplementation. Our findings conclude that Vit-C was effective in improving hyperglycemia and hyperlipidemia recommending the supplementation of Vit-C in addition to regular management of diabetic patients as a therapeutic measure preventing associated complications.

Index Terms—Diabetes, Hyperglycemia, Hyperlipidemia, Vitamin-C

Cite: Shreyasi Vaksh, Mukesh Pandey, U. S. Zingade, and Varikasuvu Seshadri Reddy, "The Effect of Vitamin-C Therapy on Hyperglycemia, Hyperlipidemia and Non High Density Lipoprotein Level in Type 2 Diabetes," International Journal of Life Sciences Biotechnology and Pharma Research, Vol. 2, No. 1, pp. 290-295, January 2013.
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