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Advantages of Paclitaxel-Loaded Nano Niosomes to Nanoliposomal Formulation: An In Vitro Study

Zarei M.1, Norouzian D.2, Chiani M.2, Ebrahimi H.2, Mohammadi M.3, and and Akbarzadeh A.2
1. Chemical Engineering Department, Shahrood Unit, Islamic Azad University, Shahrood, Iran.
2. Pilot Nano-Biotechnology Department, Pasteur Institute of Iran, Tehran-13164, Iran.
3. Chemical Engineering Department, Marvdasht Unit, Islamic Azad University, Marvdasht, Iran.
Abstract—In this study, paclitaxel was loaded into nanoniosom and liposomes employing ether injection method. The average diameters of pegylated and non pegylated nano particles of niosomes and liposomes were determined to be 146.9, 211.5, 361.3 and 410.7 nm respectively. The rates of encapsulation were considerably high in both the formulations as such the percentages of paclitaxel entrapped in pegylated and non pegylated niosomal and liposomal forms were estimated to be 96.3, 98.9, 80.4 and 84.7 respectively. The release of drug and toxicity of the formulated paclitaxel were studied by dialysis and MTT methods. The amounts of drug released from pegylated and non pegylated niosomes and liposomes were calculated to 12, 10.6, 23 and 20.2 % during 48 h respectively. The IC 50 in niosomal and liposomal nanoparticles 2.5 and 1.5 folds were decreased in relation to free drugs respectively. This study showed that prepared niosomal paclitaxel was more effective than that of liposomal. Apart from nano carrier both the formulation can be considered for further in vivo studies.

Index Terms—PEG-noisome, PEG-Liposome, Size distribution, Encapsulation efficiency

Cite: Zarei M., Norouzian D., Chiani M., Ebrahimi H., Mohammadi M., and Akbarzadeh A., "     Advantages of Paclitaxel-Loaded Nano Niosomes to Nanoliposomal Formulation: An In Vitro Study," International Journal of Life Sciences Biotechnology and Pharma Research, Vol. 2, No. 1, pp.335-342, January 2013.
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