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Ameliorative Effects of Ethanol Leaf Extract of Moringa oleifera on the Liver and Kidney Markers of Malaria Infected Mice

Ugwu Okechukwu P. C., Nwodo Okwesili F. C., Joshua Parker E., Odo Christian E., Ossai Emmanuel C., and Bawa Aburbakar
Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria.
Abstract—The ameliorative properties of ethanol leaf extract of Moringa oleifera on the malaria infected liver and kidney injuries of mice were analysed. The experimental animals were divided into six groups with each group consisting of four mice. Groups 1 (positive control) and 6 (negative control) were treated with 5mg/kg body weight of distilled water, group 5 (standard control) was treated with 5mg/kg body weight of artesunate while groups 2 ,3 and 4 were treated with 45,90 and 180 mg/kg body weight of Moringa oleifera ethanol leaf extract .The results showed that kidney marker of serum creatinine increased significantly (p\<0.05) in group 1 (positive control) compared to group 6 (negative control) and other groups. Group 6 (negative control) showed a non-significant difference (p>0.05) in serum urea compared to group 1 (positive control) and other groups. Liver marker of total bilirubin (TB) increased significantly (p\<0.05) in group 1 (positive control) and group 2 (45mg/kg body weight of the extract) compared to group 6 (negative control) and other groups. Alanine aminotransferase (ALT) also, significantly increased (p\<0.05) in group 1 (positive control) and group 2 (45mg/kg body weight of the extract when compared to group 6 (negative control). Group 6 (negative control) showed no significant difference (p>0.05) in aspartate aminotransferase (AST) compared to group 1 (positive control) and other groups. Alkaline phosphatase (ALP) activity of mice significantly increased (p\<0.05) in group 1 (positive control) and group 4 (180mg/kg body weight of the extract ) compared to group 6 (negative control) and other groups.

Index Terms—Moringa oleifera , Liver marker, Kidney marker, Malaria

Cite: Ugwu Okechukwu P. C., Nwodo Okwesili F. C., Joshua Parker E., Odo Christian E., Ossai Emmanuel C., and Bawa Aburbakar, "Ameliorative Effects of Ethanol Leaf Extract of Moringa oleifera on the Liver and Kidney Markers of Malaria Infected Mice," International Journal of Life Sciences Biotechnology and Pharma Research, Vol. 2, No. 2, pp. 43-52, April 2013.
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