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Hypoglycaemic Activity of Orally Administered Woodfordia fruticosa Flower Extract in Alloxan-Induced Diabetic Mice

Aruna Bhatia and Nishu Khera
Immunology and Immunotechnology Laboratory, Department of Biotechnology, Punjabi University, Patiala-147 002, Punjab, India.
Abstract—Woodfordia fruticosa isa high altitude plant belonging to family Lythraceae that has been used as folkloric medicine for many ailments and diseases. In the present study, the hypoglycaemic effect of orally given flower extract of Woodfordia fruticosa in alloxan induced diabetic mice has been assessed. Flower extract was administered orally at variable doses in mice with or without combination with glyburide to different groups of mice (normal and alloxan treated diabetic mice). The blood glucose level, body weight, mortality rate and Oral glucose tolerance test (OGTT) was monitored in various groups. Results showed that the extract also possess a dose dependent hypoglycaemic effect and also a synergistic with drug (glyburide). The administration of extract also reduced the weight loss and mortality rate and augmented the glucose tolerance in both normal and diabetic mice. These results suggested that, the extract possess the synergistic hypoglycaemic activity.

Index Terms—Antidiabetic activity, Diabetic mice, Oral glucose tolerance test, Woodfordia fruticosa

Cite: Aruna Bhatia and Nishu Khera, "Hypoglycaemic Activity of Orally Administered Woodfordia fruticosa Flower Extract in Alloxan-Induced Diabetic Mice," International Journal of Life Sciences Biotechnology and Pharma Research, Vol. 2, No. 2, pp. 72-84, April 2013.
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