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Effect of Quercetin on Micronucleus Study in Mice

Srinivas H R1, Muralidhar S Talkad2, Ishwarya M S2, Sanober Samreen2, Sharvani2, and Umesh H R2
1. CMJ University, Shillong, India
2. PG Department of Biotechnology, R&D Center,Dayananda Sagar College of Biological Sciences, Kumaraswamy Layout, Bangalore-560078, India
Abstract—The present investigation planned for the possible chemoprotective activity of orally administered quercetin against Cyclophasphamide-induced cyto- and genotoxicity towards mouse somatic cells in vivo. DNA strand breaks, micronuclei formation, and mitotic activity were undertaken in the current study as markers of cyto- and genotoxicity. The frequency of micronucleated polychromatic erythrocytes (MNPCEs) and the ratio of polychromatic erythrocytes to normochromatic erythrocytes (PCE/NCE) were also evaluated. The micronucleus assay revealed that all doses of the extract tested presented no genotoxic activity; in addition, the two highest doses reduced the MNPCEs and increased the PCE/NCE ratio in the bone marrow and restored. The biochemical and cytogenetic determinations were carried out 24 h after CYP injection. The results of the present study suggested that the quercetin and have a protective effect against CYP-induced oxidative stress and genotoxicity. Quercetin was neither cytotoxic nor genotoxic in mice at doses tested. Pretreatment of mice with quercetin significantly reduced Cyclophasphamide -induced genotoxicity and cytotoxicity in bone marrow cells, and these effects were dose dependent. Moreover, prior administration of quercetin ahead of Cyclophasphamide challenge ameliorated oxidative stress markers. In conclusion, Quercetin has a protective role in the abatement of Cyclophasphamide -induced cyto and genotoxicity in mice the bone marrow cells. Based on these studies Quercetin could be an ideal antioxidant derivative drug to decrease the Cyclophasphamide -induced bone marrow suppression in anti-cancer therapy. 

Index Terms—quercetin, cyclophasphamide, anti-cancer therapy, genotoxicity, cytotoxicity MNPCEs, PCE/NCE

Cite: Srinivas H R, Muralidhar S Talkad, Ishwarya M S, Sanober Samreen, Sharvani, and Umesh H R, "Effect of Quercetin on Micronucleus Study in Mice," International Journal of Life Sciences Biotechnology and Pharma Research, Vol. 2, No. 3, pp. 257-263, July 2013.
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