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Extraction and Cytotoxicity Potential of Marigold Flower (Calendula officinalis) against Breast Cancer Cell Line (MCF 7)

M Mithirai and R Arulvel
Department of Biotechnology, K S Rangasamy College of Technology, Tiruchengode, Tamilnadu, India
Abstract—The major source for lutein is marigold flower (Calendula officinalis). Lutein is a form of diesters and they are used as food colorant. They have many medicinal values and pharmacological activity. The present study deals with the extraction of lutein from the flower and the purification of compounds by thin layer chromatography and gas chromatography. The cell viability assay from the flower extract obtained was treated against breast cancer cell line (MCF 7). Thin layer chromatography was done and green color spot was observed and it was identified as lutein. GC-MS analysis was performed and these contains compounds were identified as diesters of lutein. Acetone extract was treated for cytotoxicity study against breast cancer cell line and the IC50 value is 79.5µg/ml. 

Index Terms—calendula officinalis, lutein, diesters, breast cancer, cytotoxicity, IC50

Cite: M Mithirai and R Arulvel, "Extraction and Cytotoxicity Potential of Marigold Flower (Calendula officinalis) against Breast Cancer Cell Line (MCF 7)," International Journal of Life Sciences Biotechnology and Pharma Research, Vol. 2, No. 3, pp. 393-400, July 2013.
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