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Synthesis of 4-(4-Chlorophenyl)-4-Hydroxy Piperdine Analogues Having Promising Compatibility with Alpha Amylase Enzyme

Kiran Rafiq1, Zafar Saied Saify2, Faiyaz Vaid3, Farzana Navaid2, Arfa Kamil4, Rana Kausar4, and Asghari Ghous4
1. Dow College of Pharmacy, Dow University of Health Siences, Karachi, Pakistan
2. HEJ Research Institute of Chemistry, University of Karachi, Pakistan
3. Pharmaceutical Chemistry department, Faculty of Pharmacy, University of Karachi, Pakistan
4. Federal Urdu University of Arts, Science and Technology (FUUAST), Karachi, Pakistan
Abstract—A new sequence of 4-(4'-Chlorophenyl)-4-hydroxy piperdine derivatives (II-V) were synthesized with different phenacyl halide and these newly synthesized compounds were characterized by analytical and spectroscopic data. The desired therapeutic target of the synthesized moieties can be achieved by providing a good bioavailability. When drug taken orally, first interacts with alpha amylase enzyme. The excellent compatibility of compounds with this digestive enzyme in vivo assures the enhanced ADME. Hence the synthesized compounds were screened for their in vitro antiamylatic activity by semiquantitative agar plate method and the results showed tremendous interface between them for promising receptor binding. 

Index Terms—bioavailability, ADME, in vivo, antiamylatic activity

Cite: Kiran Rafiq, Zafar Saied Saify, Faiyaz Vaid, Farzana Navaid, Arfa Kamil, Rana Kausar, and Asghari Ghous, "Synthesis of 4-(4-Chlorophenyl)-4-Hydroxy Piperdine Analogues Having Promising Compatibility with Alpha Amylase Enzyme," International Journal of Life Sciences Biotechnology and Pharma Research, Vol. 2, No. 3, pp. 459-465, July 2013.
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