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Evaluation of Antimutagenic Activity of Orange Peel Extract Using Ames Salmonella Microsome Assay

B Geetha and K S Santhy
Department of Zology, Avinashilngam Instiute for Home Science and Higher Education for Women, Coimbatore 641043, India
Abstract—In the present investigation, antimutagenic efect of petroleum ether, chloroform, methanol and water extracts of orange pel was evaluated in Salmonela typhimurium TA-98 and TA-10 strains. Wel known mutagens like sodium azide and daunomycin were aded at a concentration of 10 µl and 6 µl per plate respectively resulted in the induction of histidine revertant colonies. However aditon of 10 µl of petroleum ether, chloroform, ethanol and water extracts of orange pel to 10 µl of sodium azide and 6 µl of daunomycin treated plates resulted in the inhibiton of number of histidine revertant colonies. Furthermore, suplementation with al the four extracts of orange pel at a concentration of 10 µl per plate respectively in the presence of S9 fraction also led to signifcant inhibiton in sodium azide and daunomycin induced colony formation. The antimutagenic activity of ethanolic extract of orange pel was found to be higher than that of the other extracts. Hence the study revealed that orange pel has protective eficacy in sodium azide and daunomycin induced mutagenicity in the test microbial system. 

Index Terms—orange peel, antimutagenic activity, ames asay, salmonela typhimurium

Cite: B Geetha and K S Santhy, "Evaluation of Antimutagenic Activity of Orange Peel Extract Using Ames Salmonella Microsome Assay," International Journal of Life Sciences Biotechnology and Pharma Research, Vol. 2, No. 3, pp. 466-471, July 2013.
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