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Antifungal Screening of Curcuma longa and Cassia Tora on Dermatophytes

Sagarika Rath1 and R C Mohanty2
1. Indira Gandhi Institute of Pharmaceutical Sciences, Bhubaneswar-15, Odisha
2. Emeritus Scientist, PG Department of Botany, Utkal University, VaniVihar, Bhubaneswar, Odisha
Abstract—This study evaluated antifungal screening of Curcuma longa L and Cassia tora L. against two dermatophytes, rhizome and leaf of these plants were taken and extraction were made in different solvents like water, petroleum ether, chloroform and ethanol were tested against Trichophyton mentagrophytes MTCC No. 8476 and Epidermophyton floccosum MTCC No. 613. The preliminary screening by Poison Food Technique revealed that the ethanol extract of the Curcuma longa rhizome and chloroform extract of Cassia tora leaf showed excellent antimycotic activity against Trichophyton mentagrophytes and Epidermophyton floccosum. Petroleum ether extract of Cassia tora showed zone of 10 mm and 20 mm against Trichophyton mentagrophytes and Epidermophyton floccosum. The antibiogram profile indicated that Terbinafine has the maximum activity as is shown by its zone of inhibition viz., 40 mm and 32 mm for Trichophyton mentagrophytes and Epidermophyton floccosum, respectively. Fluconazole was found to be ineffective against the two-test fungi. Lowest MIC in case of ethanolic extract of Curcuma longa against Trichophyton mentagrophytes and Epidermophyton floccosum is 6.575 µg/ml and the chloroform extract of Cassia tora against Trichophyton mentagrophytes is 13.15 µg/ml. 

Index Terms—antibiogram, leaf extract, MIC, rhizome extract

Cite: Sagarika Rath and R C Mohanty, "Antifungal Screening of Curcuma longa and Cassia Tora on Dermatophytes," International Journal of Life Sciences Biotechnology and Pharma Research, Vol. 2, No. 4, pp. 88-94, October 2013.
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