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In Vivo Antimanic Activity of Lithium and Carbamazepine in Ketamine Induced Mania in Wistar Albino Rats

Harshalkumar Mahajan and Shrikant Pawar
Pharmacology Institute, Sinhgad Technical Education Society’s, Smt. Kashibai Navale College of Pharmacy, Pune, India
Abstract—Bipolar Disorder (BD) is an affective disorder that causes unusual shifts in a person's mood energy and ability to function. It is characterized by manic or depressive episodes such as euphoria irritability, aggressiveness or hyperactivity. The present study investigate effect of the mood stabilizers lithium and carbamazepine (CBZ) in ketamine induced hyperactivity as novel animal model of mania. In the reversal treatment, rats were treated with ketamine (25 mg/kg i.p) and saline for 14 days. Between the 8th and 14th day, animals from control and ketamine only group were treated with lithium carbonate (47.5 mg/kg; i.p, twice a day) and carbamazepine (25 mg/kg; i.p, twice a day). In reversal treatment, lithium (p < 0.01) and CBZ (p < 0.001) significantly decreases the ketamine induced hyperactivity when tested using actophotometer. In dominance test, lithium and CBZ treated animals were found to be less dominated (33%) and (50%) when compared to ketamine treated animals (100%). Lithium and CBZ significantly reverses the ketamine induced TBARS formation (p < 0.001), but no significant rise in catalase activity was observed in lithium and CBZ groups. The lithium and CBZ showed significant reduction in the serum FSH level (p < 0.05) but no significant change in the level of serum prolactin, cortisol and LH concentration was observed. CBZ significantly reduces serum cortisol level (p < 0.05) as compare to control group. The studies confirm the antimanic activity of lithium and carbamazepine against ketamine induced mania. 

Index Terms—mania, carbamazepine, ketamine, lithium

Cite: Harshalkumar Mahajan and Shrikant Pawar, "In Vivo Antimanic Activity of Lithium and Carbamazepine in Ketamine Induced Mania in Wistar Albino Rats," International Journal of Life Sciences Biotechnology and Pharma Research, Vol. 2, No. 4, pp. 117-126, October 2013.
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