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Haematological Effects of Fluted Pumpkin (Telfairia occidentalis) Leaves in Rats

Obeagu Emmanuel Ifeanyi1, Chikelu Ifeoma M2, obarezi Thompson Ndubuisi3, Ogbuabor Bernice Nwakaego4, and Anaebo Queen Braxton N5
1. Diagnostic Laboratory Unit, Department of University Health Services, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria
2. Department of Medical Laboratory Science, Faculty of Health Sciences, Madonna University, Elele Campus, Elele, Rivers State, Nigeria
3. Medical Doctor, Department of University Health Services, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria
4. Department of Medical Laboratory Science, ESUT Teaching Hopital Parklane,Enugu State, Nigeria
5. Medical Doctor Department of Accident and Emergency Lagos State University Teaching Hospital, Nigeria
Abstract—The effects of different concentrations of ethanol extract of fluted pumpkin (Telfairia occidentalis) leaves on some haematological parameters: Packed Cell Volume (PCV), Haemoglobin (Hb) concentrations, Total White Blood Cell (TWBC) count and Platelet count were evaluated using 16 Wister strain albino rats as subjects. In the experiment, the rats were divided into 4 groups of 4 rats each and the rats were served different concentrations of T. occidentalis ethanol extract for seven (7) days. The result showed that the group of rats which received 300 mg/kg and 200 mg/kg leaves extract had a significant increase (p<0.05) in PCV and Hb concentration, those administered 100 mg/kg of the extract had significant increase (p<0.05) in PCV only. There was no significant increase (p<0.05) in the WBC and platelet counts of all the groups when compared with the control. It therefore follows that T. occidentalis has haematopoietic properties. 

Index Terms—telfairia occidentalis, packed cell volume (PCV), haemoglobin (Hb) concentrations, total white blood cell (TWBC) count, platelet count

Cite: Obeagu Emmanuel Ifeanyi, Chikelu Ifeoma M, obarezi Thompson Ndubuisi, Ogbuabor Bernice Nwakaego, and Anaebo Queen Braxton N, "Haematological Effects of Fluted Pumpkin (Telfairia occidentalis) Leaves in Rats," International Journal of Life Sciences Biotechnology and Pharma Research, Vol. 3, No. 1, pp. 172-182, January 2014.
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