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Evaluation of the Anti-Ulcer Activity of Ocimum sanctum Linn (Tulsi) In Indomethacin-Induced Gastric Ulcers in Albino Rats

Mrutyunjay M Mirje1 and Sameer Uz Zaman2
1. Department of Pharmacology, Institute of Medical Science and Research, Mayni, Tal- Katva, Dist- Satara. 415102
2. Kamineni Academy of Medical Science and Research Centre, L B Nagar, Hyderabad 500068
Abstract—Background and Objectives: Peptic Ulcer Disease (PUD) encompassing gastric and duodenal ulcer is the most prevalent gastrointestinal disorder. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) such as indomethacin are used in the treatment of inflammation, fever and pain. However, NSAIDs cause gastric damage as a major adverse reaction. In this study, the gastro protective effect of O. sanctum was also studied and compared with omeprazole in model of indomethacin-induced ulceration. Materials and Methods: This study was conducted at Navodaya Medical College and Research Centre for a period of two years. The gastro protective effect of aqueous extract of O. sanctum was studied using model of indomethacin-induced gastric damage and compared with omeprazole. O. sanctum (200 mg/kg or 400 mg/kg) or omeprazole (10 mg/kg) were administered alone in separate group of rats. Results: O. sanctum showed significant (p < 0.05) protective effect against indomethacin-induced gastric ulcer when compared to control. The gastro protective effect of O. sanctum was comparable with that of omeprazole, the standard drug. Conclusion: O. sanctum showed significant gastro protective effect against indomethacin-induced gastric damage possibly due to its 5-lipoxygenase inhibitory effect, mucoprotective activity and its antisecretory effect. 

Index Terms—ocimum sanctum linn (Tulsi), indomethacin, gastric damage, omeprazole, short running title, anti-ulcer activity of ocimum sanctum

Cite: Mrutyunjay M Mirje and Sameer Uz Zaman, "Evaluation of the Anti-Ulcer Activity of Ocimum sanctum Linn (Tulsi) In Indomethacin-Induced Gastric Ulcers in Albino Rats," International Journal of Life Sciences Biotechnology and Pharma Research, Vol. 3, No. 1, pp. 274-279, January 2014.
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