Evaluation of the Anti-Inflammatory Effect of Zingiber officinale (Ginger) Root in Rats - Volume 3, No.1, January, 2014 - IJLBPR
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Evaluation of the Anti-Inflammatory Effect of Zingiber officinale (Ginger) Root in Rats

Sameer Uz Zaman1 and Mrutyunjay M Mirje2
1. Department of Pharmacology, Kamineni Academy of Medical Sciences and Research Centre, L B Nagar, Hyderabad 500068
2. Department of Pharmacology, Institute of Medical Science and Research, Mayni. Tal-Katva, Dist- Satara 415102
Abstract—Aims and objectives: The purpose of this study was to evaluate and compare the anti-inflammatory activity of extract of Zingiber officinale (ginger) in experimental acute inflammatory animal model. Materials and Methods: In this study, the anti-inflammatory activity of Zingiber officinale alone and in combination with indomethacin was studied using carrageenan-induced rat paw oedema. Aqueous extract of Zingiber officinale (200 mg/kg or 400 mg/kg) was administered alone and in combination with indomethacin (25 mg/kg) to separate group of rats and paw volume was measured by a plethysmometer and compared with the control group. Results: Indomethacin, ginger 200 mg/kg and ginger 400 mg/kg displayed values of 95%, 89.5% and 92.6% inhibition of paw oedema respectively. The combinations of indomethacin with ginger 200 mg/kg and indomethacin with ginger 400 mg/kg displayed values of 95% and 97.5% inhibition of paw oedema respectively. These results indicate a similarity in the anti-inflammatory profile of ginger and indomethacin, and furthermore an enhanced anti-inflammatory profile when both are combined. Conclusion: As ginger root showed significant anti-inflammatory activity in the model studied, it can be investigated further as a promising anti-inflammatory agent. 

Index Terms—zingiber officinale, anti-inflammatory, carrageenan, indomethacin, ginger

Cite: Sameer Uz Zaman and Mrutyunjay M Mirje, "Evaluation of the Anti-Inflammatory Effect of Zingiber officinale (Ginger) Root in Rats," International Journal of Life Sciences Biotechnology and Pharma Research, Vol. 3, No. 1, pp. 292-298, January 2014.
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