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Protective Effect of Hydroalcoholic Extract of Ephedra Major On an Experimental Model of Bile Duct Ligation in Rats

Maziyar Hassanzadeh1, Mahin Dianat2, Parvin Torabizadeh1, and Mohammad Badavi2
1. Department of Biology, Faculty of Science, Islamic Azad University, Karaj Branch, Karaj, Iran
2. Department of Physiology, Physiology Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Abstract—Introduction: The liver regulates several important functions such as metabolism. Liver cirrhosis has most cardiovascular complications. Medicinal plants, due to their low side effects, have been used as alternative to chemical drugs. Ephedra major with flavonoids compounds have effective role in treatment of many diseases. Aims and objectives: The aim of this study was to investigate the effect of hydroalcoholic extract of Ephedra major on laboratory (serum bilirubin) and pathological parameters on a model of induced cholestasis in rats. Materials and Methods: In this study, 40 male Sprague Dawley rats (200-250 g) were divided into 5 groups: sham (normal saline, 1 mL/kg/ day), cirrhotic (normal saline, 1 mL/kg/day), extract (200 mg/kg/day), cirrhotic treated with extract (100 and 200 mg/kg/day). Biliary cirrhosis in animals induced by chronic (4-weeks) Bile Duct- Ligation (BDL). The extracts and normal saline were gavaged for 15 consecutive days. In all groups, 4 weeks after surgery, animals anesthetized and blood samples were collected from the rat’s heart for measure serum bilirubin in plasma and the liver was isolated and immersed in 10% formalin solution and stained by haematoxiline-eosine (H&E) method then histopathological parameters was investigated. Results were analyzed by using student t-test and one way ANOVA. P<0.05 was considered as significant level. Results: After induced of BDL, Results showed that laboratory and pathological parameters in the cirrhotic group significantly increased compared to sham group. Laboratory and pathological parameters were reduced in cirrhotic groups treated with extract compared to cirrhotic group. Conclusion: Significant decrease in laboratory and pathological parameters in BDL group treated by hydroalcoholic extract of Ephedra major suggests the protective effect of Short-term consumption of low dose Ephedra major in cirrhotic patients. 

Index Terms—ephedra major, biliary cirrhosis, bilirubin, pathological parameters, rat

Cite: Maziyar Hassanzadeh, Mahin Dianat, Parvin Torabizadeh, and Mohammad Badavi, "Protective Effect of Hydroalcoholic Extract of Ephedra Major On an Experimental Model of Bile Duct Ligation in Rats," International Journal of Life Sciences Biotechnology and Pharma Research, Vol. 3, No. 2, pp. 44-50, April 2014.
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