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Malaria Resistance and Sickle Cell Trait: A Review

Otoikhian C S O1, Osakwe A A2, Utieyin M C1, and Igue U B2
1. Department of Biological Sciences, Novena University, Ogume, Delta State, Nigeria
2. Department of Chemical Sciences, Novena University, Ogume, Delta State, Nigeria
Abstract—Sickle cell disease or sickle cell anaemia is an autosomal recessive disease caused by haemoglobin S, an oxygen-carrying protein in blood cells. A single point mutation in the nucleobase sequence of chromosome 11 (Eleven) causes the sixth amino acid in the haemoglobin protein, glutamine acid, to be replaced by valine, changing standard haemoglobin beta into haemoglobin S. Translocation of sickle cell erythrocyte MicroRNAs into plasmodium falciparum inhibits parasite translation and contributes to malaria resistance. Elucidation of this mechanism can lead to a better understanding of sickle cell trait protection against plasmodium falciparum infection. 

Index Terms—malaria resistance, sickle cell anaemia, sixth amino acid

Cite: Otoikhian C S O, Osakwe A A, Utieyin M C, and Igue U B, "Malaria Resistance and Sickle Cell Trait: A Review," International Journal of Life Sciences Biotechnology and Pharma Research, Vol. 3, No. 3, pp. 52-71, July 2014.
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