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Preparation and Evaluation of Orally Disintegrating Tablets of Isoniazid

A M Suthar1 and M M Patel2
1. Officer Regulatory affairs, Par Laboratories, Gozaria, Gujarat
2. ShankersinhVaghela Bapu Institute of Technology, Gandhinagar, Gujarat, India
Abstract—The purpose of this research was to develop and evaluate pediatric formulation by masking the bitter taste of Isoniazid. Non-compliance of therapy of tuberculosis which is mostly associated with bitter taste can lead to worsening of diseased condition in children. The taste masking was done by preparing solid dispersion of drug with β-Cyclodextrin by kneading method. All the tablets were prepared by direct compression method with single punch machine using flat faced punches. The prepared tablets were evaluated for friability, disintegration time, drug content, dissolution, taste evaluation and FTIR. Solid dispersion was optimized for taste masking by time intensity method of taste evaluation. The selected formula was subjected to stability study for three months which showed no significant changes in the tablet physical properties and drug dissolution. 

Index Terms—isoniazid, taste masking, β-cyclodextrin and pediatric

Cite: A M Suthar and M M Patel, "Preparation and Evaluation of Orally Disintegrating Tablets of Isoniazid," International Journal of Life Sciences Biotechnology and Pharma Research, Vol. 3, No. 3, pp. 92-97, July 2014.
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