Preparation and Evaluation of Powder of Unripe Fruits of Various Varieties of Musa paradiasiaca L. (Banana and Plantain) as a Tablet Disintegrant - Volume 3, No.3, July, 2014 - IJLBPR
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Preparation and Evaluation of Powder of Unripe Fruits of Various Varieties of Musa paradiasiaca L. (Banana and Plantain) as a Tablet Disintegrant

Meera Chandradatt Singh1, Shankar Eknath Pawar2, and NareshHiraram Choudhary3
1. Department of Pharmaceutics STES's Smt. Kashibai Navale College of Pharmacy Kondhwa [Bk], Pune-48, Maharashtra, India
2. Department of Pharmaceutics M. Pharm. (IV sem) STES's Smt. Kashibai Navale College of Pharmacy Kondhwa [Bk], Pune-48, Maharashtra, India
3. Department of PharmaceuticsM. Pharm. STES's Smt. Kashibai Navale College of Pharmacy Kondhwa [Bk], Pune-48, Maharashtra, India
Abstract—The present investigation was aimed at evaluating the feasibility of powder of three varieties of Musa paradisiaca L. in their unripe state as tablet disintegrant while formulating Orally Disintegrating Tablet (ODT) and other fast disintegrating dosage forms. The powders obtained were characterized for flow property, compressibility, swelling capacity, hydration capacity and moisture content. ODTs (without drug) were prepared by direct compression techniques using three varieties of M. paradisiaca L. in 10% w/w concentration. The variety showing promising results (in this fixed concentration) for hardness, friability, in vitro disintegration time, wetting time and water absorption ratio was selected as potential tablet disintegrant. Dummy tablets were also evaluated for thickness and diameter. All the three varieties were studied for drug excipient compatibility with Rezatriptan Benzoate as a model drug. The (SP2) variety showed the most promising results and can be concluded as potential superdisintegrant from natural origin 

Index Terms—Musa paradisiaca L., Musa fruits in unripe state, tablet disintegrant, orally disintegrating tablets, rizatriptan benzoate

Cite: Meera Chandradatt Singh, Shankar Eknath Pawar, and NareshHiraram Choudhary, "Preparation and Evaluation of Powder of Unripe Fruits of Various Varieties of Musa paradiasiaca L. (Banana and Plantain) as a Tablet Disintegrant," International Journal of Life Sciences Biotechnology and Pharma Research, Vol. 3, No. 3, pp. 113-125, July 2014.
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