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Design and Development of Oral Disintegrating Tablets of Rizatriptan Benzoate Using Powder of Musa Paradiasiaca L. (Plantain) Alone and in Combination with Other Synthetic Superdisintegrants: A Comparative Study

Meera Chandradatt Singh1, Shankar Eknath Pawar2, and NareshHiraram Choudhary1
1. Department of Pharmaceutics STES's Smt. Kashibai Navale College of Pharmacy Kondhwa [Bk], Pune-48, Maharashtra, India
2. Department of Pharmaceutics M. Pharm. (IV sem) STES's Smt. Kashibai Navale College of Pharmacy Kondhwa [Bk], Pune-48, Maharashtra, India
Abstract—The study in this research paper is an extension of a study where different varieties of raw fruits of musa paradiasiaca. L .were studied and one of the variety designated as (SP2) was judged as the best amongst all. This powder of (SP2) variety was further investigated in this study. It showed property to act as superdisintgrants and so was compared with commercially available three superdisintgrants. When (SP2) was alone used in 15% concentration gave the best results of 85 s as disintegration time. Though it is accepted in most of the pharmacopoeias, combination of (SP2) powder was done with other synthetic superdisintegrants in which combination with Crospovidone gave the best disintegration time well below 50 s. Concentration of Crospovidone with (SP2) powder was optimized using factorial design in which (OP6) batch gave the best results. The drug selected in this study was Rizatriptan Benzoate, an antimigraine drug which was developed as orally disintegrating tablet. In this study Rizatriptan benzoate did not show any incompatibility and interaction with (SP2) variety. The stability studies and other physical parameters of (SP2) were promising and thus (SP2) can be considered as a potential superdisintgrant and a tablet excipient in various novel tablet formulations. Promise of (SP2) variety also lies in the fact that it is obtained from natural sources and is available throughout the world and is nontoxic and economical. 

Index Terms—Musa paradiasiaca L., superdisintegrant, crospovidone, ODT'S, excipients, rizatriptan benzoate, natural sources

Cite: Meera Chandradatt Singh, Shankar Eknath Pawar, and NareshHiraram Choudhary, "Design and Development of Oral Disintegrating Tablets of Rizatriptan Benzoate Using Powder of Musa Paradiasiaca L. (Plantain) Alone and in Combination with Other Synthetic Superdisintegrants: A Comparative Study," International Journal of Life Sciences Biotechnology and Pharma Research, Vol. 3, No. 3, pp. 161-180, July 2014.
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