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Investigation of Antimycobacterial and Cytotoxicity Activity of Bersama Abyssinica Fresen Extracts from Tanzania

Never Zekeya Mwambela, Musa Chacha, and Francis Shahada
Nelson Mandela African Institute of Science and Technology, School of Life Science and Bio-engineering, PO Box 447, Arusha, Tanzania
Abstract—Bersama abyssinica is widely used for treatment of various infectious diseases in Africa. In Tanzania Bersama abyssinica Fressen subsp. paullinioides is locally used for treatment of various infectious diseases including Mycobacterial illness though the plant has never been investigated for antimycobacterial activity. Hence, this study was conducted to evaluate antimycobacterial and cytotoxicity activity of Bersama abyssinica Fresen subsp. paullinioides leaves, stem bark and root bark extracts. Leaves, stem bark and root bark were sequentially extracted with petroleum ether, ethyl acetate and methanol. Nine extracts were obtained and tested against the two fast growing Mycobacteria species namely; Mycobacteria madagascariense and Mycobacterium indicus pranii by using micro dilution method in which the Minimum Inhibitory Concentrations (MICs) were determined. The result showed all extracts exhibited antimycobacterial activity against Mycobacterium madagascariense and Mycobacteria indicus pranii with MIC ranging from 0.39 to 6.25 mg/mL and 0.19 to 6.25 mg/mL respectively. The brine shrimp lethality result obtained had the LC50 value ranging from 30 to > 100 μg/mL indicating that extracts were mildly toxic to non toxic. The present results support the use of Bersama abyssinica Fresen subsp. paullinioides by local communities for management of Tuberculosis and suggest that the methanolic extracts could be a potential source of antimycobacterial agents. Based on the cytotoxicity analysis, Bersama abyssinica extracts pose no threat for human healthy and are considered as non toxic. 

Index Terms—bersama abyssinica Fresen, mycobacterium tuberculosis, cytotoxicity, extracts

Cite: Never Zekeya Mwambela, Musa Chacha, and Francis Shahada, "Investigation of Antimycobacterial and Cytotoxicity Activity of Bersama Abyssinica Fresen Extracts from Tanzania," International Journal of Life Sciences Biotechnology and Pharma Research, Vol. 3, No. 4, pp. 23-32, October 2014.
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