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Changes in Cytokine Expression in Rats Administered Extracts of Termitomyces Robustus and Ocimum gratissimum

Simeon I Egba1, Chidiebere E Ugwu2, and Fidelis D Ihediwa1
1. Department of Biochemistry, College of Natural and Applied Sciences, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria
2. Department of Human Biochemistry, Faculty of Basic Medical sciences, College of Health Sciences, Nnamdi Azikiwe University Awka, Anambra State, Nigeria
Abstract—The study evaluated the immunomodulatory activities of extracts of Termitomyces robostus and Ocimum gratissimum on Wistar albino rats. A total of twenty Wistar albino rats were randomly grouped into five groups. The positive control was administered normal saline while the negative control received pyrogallol to suppress the immune system. Group one and two received 100 and 300 mg/kg body weight of methanol extract of Ocimum gratissimum and 10% pyrogallol while group three received 300 mg/kg body weight of Termitomyces robostus and 10% pyrogallol. The immunological activity was evaluated on cytokine expression and haemaglutination titre. The study lasted for 21 days. Significant (p<0.05) increases were induced by the 300 mg/kg body weight administration of both extracts on serum interleukin-2, interferon-γ, and tumor necrosis factor-α. The two doses administration of Termitomyces robostus resulted in significant (p<0.05) decrease in delayed type hypersensitivity while the administration of Ocium gratissimum increased (p>0.05) the delayed type hypersensitivity. The primary and secondary antibody titres showed significant (p<0.05) increase. These comparisons were made against the negative control. The results from the study demonstrate that the extracts of Termitomyces robostus and Ocimum gratissimum possess immunostimulatory effects. These effects may be the reason for their use in traditional medicine. 

Index Terms—cytokines, termitomyces robostus, ocimum gratissimum

Cite: Simeon I Egba, Chidiebere E Ugwu, and Fidelis D Ihediwa, "Changes in Cytokine Expression in Rats Administered Extracts of Termitomyces Robustus and Ocimum gratissimum," International Journal of Life Sciences Biotechnology and Pharma Research, Vol. 3, No. 4, pp. 182-193, October 2014.
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