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Antibacterial Activity Lactic Acid Bacteria (LAB) Isolated Native Yogurt against ESBL Producing E. coli Causing Urinary Tract Infection (UTI)

Heshmatipour Z1, Aslikousha H2, Mohamadiebli F3, and Ashrafi Eslami A4
1 Department of Microbiology, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran
2 Msc. Microbiology, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran
3 Department of Microbiology, Infection Control Comimittee, Pars Hospital Laboratory, Tehran, Iran
4 Bsc. Genetic, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran
Abstract—The Lactic Acid Bacteria (LAB) is well known probiotics with beneficial effects to human health. Their antimicrobial activity is one of the most important probiotic characteristics. Urinary tract infections (UTIs) are the most frequent bacterial infections encountered in community settings. Extended spectrum β-lactamases (ESBLs) are enzymes produced by pathogenic bacteria that are capable of hydrolyzing oxyimino-cephalosporins, and are inhibited by β-lactamase inhibitors. Microbial products have used the best source for therapeutic agents worldwide. The lactic acid bacteria were isolated from native yogurt in North IRAN. Theantimicrobial activity of cell-free supernatant and partially purified bacteriocin was determined by well diffusion method. All isolated ESBL were processed and identified as per the standard bacteriological division of microbiology lab. The bacteria were primarily identified by colony morphology, microscopy of Gram`s stain and routine biochemical tests and antibiotic disk sensitivity tests. The current study showed that ESBL E. coli resistant to Cefazoline (96.6%), Ceftazidime (43.3%), Ceftriaxone (3.3%), Ciprofloxacin (76.6%), Gentamicin (26.6%), Meropenem (0%), Tobramycin (43.3%), Cefotaxime (93.3%), Terimetoperim & Sulfomethoxazole (83.3%), Ceftazidime + cluvalonic acid (3.3%), Cefotaxime + cluvalonic acid (3.3%), Cefpodoxime (96.6%), Piperacillin + Tazobactam (0%), Ampicillin (100%), Amikacin (0%), Nitrofurantion (6.6%). The CFCS and PP exhibited an antibacterial effect on a narrow range of ESBL strains. However the effect is isolates the invitro is better than large number broad-spectrum antibiotics such: third-generation cephalosporins (eg, cefotaxime, ceftriaxone, ceftazidime).

Index Terms—Lactic Acid Bacteria (LAB), Urinary Tract Infection (UTI), Extended Spectrum β-lactamases (ESBLs), CFCS.

Cite: Heshmatipour Z, Aslikousha H, Mohamadiebli F, and Ashrafi Eslami A, "Antibacterial Activity Lactic Acid Bacteria (LAB) Isolated Native Yogurt against ESBL Producing E. coli Causing Urinary Tract Infection (UTI)," International Journal of Life Sciences Biotechnology and Pharma Research, Vol. 4, No. 2, pp. 117-121, April 2015.
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