Background & Objectives: Psoriasis represents a recurrent hyper-proliferative dermal condition frequently associated with the generation of free radicals, deviations in lipid metabolism, and heightened inflammatory secretions, which collectively contribute to an elevated cardiovascular risk among affected individuals. The objective of the current study was to assess the levels of serum lipids, lipoproteins, and oxidant-antioxidant statuses, as well as to elucidate their correlation with atherogenic risk markers—specifically oxidized low-density lipoprotein (oxLDL) and high-sensitivity C-reactive protein (hsCRP)—in individuals diagnosed with psoriasis. Methods: The research was undertaken involving 300 patients diagnosed with psoriasis and 300 healthy control subjects who were matched in age and sex. Fasting blood samples, collected after an overnight fast, were procured for the purpose of analyzing lipids, lipoproteins, products of lipid oxidation and peroxidation (including oxidized low-density lipoprotein, oxLDL, and malondialdehyde, MDA), antioxidant enzyme levels (such as reduced glutathione, GSH, and total antioxidant status), and for the determination of high-sensitivity C-reactive protein (hsCRP) levels. Results: The mean concentrations of atherogenic lipids, such as total cholesterol (P<0.001) and triacylglycerol (P<0.01), as well as lipid peroxidation products (P<0.001), oxidized low-density lipoprotein (oxLDL), and high-sensitivity C-reactive protein (hsCRP) levels (P<0.001), were observed to be significantly elevated in patients with psoriasis when compared to healthy control subjects. Conversely, the ferric-reducing ability of plasma (FRAP, P<0.001) and the activities of antioxidant enzymes, such as reduced glutathione (GSH, P<0.01), were observed to be significantly diminished in comparison to the healthy control group. In this cohort of patients, a positive correlation was observed between plasma oxLDL levels and both LDL cholesterol (P<0.001) and MDA (P<0.001) concentrations, while a negative association was noted with antioxidant status. Serum levels of malondialdehyde (MDA), ferric reducing ability of plasma (FRAP), and oxidized low-density lipoprotein (oxLDL) demonstrated a correlation with the risk of atherosclerosis in patients suffering from psoriasis. Nonetheless, no statistically significant association was observed between the levels of reduced glutathione (GSH) and high-sensitivity C-reactive protein (hsCRP). Conclusions: The findings of the study indicate that the oxidation of low-density lipoprotein (LDL) along with reactive oxygen species, in conjunction with inflammatory markers, may play a critical role in the induction of atherosclerosis in individuals afflicted with psoriasis.