Background and Objectives: Foot infections represent a common complication in diabetic patients, with reduced blood supply due to ischemia being a major contributing factor to disease morbidity. Peripheral vascular disease (PVD) has a higher prevalence and faster progression in diabetic patients, with prevalence varying among populations. This study aims to determine the prevalence of peripheral vascular disease in diabetic patients presenting with foot infections at a tertiary care center. Methods: This prospective analytical study was conducted at Government Stanley Medical College, Chennai, between February 2020 and February 2021. Patients admitted with diabetic foot infections who met inclusion criteria were enrolled. After documenting patient information, all subjects underwent clinical examination and lower limb arterial Doppler studies. The findings were tabulated and analyzed for correlations with various risk factors. Results: The study population comprised 73 patients (53.4% male, 46.6% female) with a mean age of 56.0±7.9 years. The prevalence of peripheral vascular disease was 31.5% among the study population, with most patients exhibiting below-knee vessel stenosis. Significant correlations were observed with age, duration of diabetes, and tobacco usage. Patients with peripheral vascular compromise demonstrated worse clinical presentations and outcomes compared to those without vascular compromise. Conclusion: A significant proportion of diabetic patients with foot infections have underlying peripheral vascular disease that may not always be clinically apparent. Early detection using arterial Doppler studies and ankle-brachial pressure index can facilitate timely intervention, potentially reducing amputation risk and improving outcomes.