Aim: This study aimed to assess the prevalence and types of knee lesions causing pain in 80 patients using magnetic resonance imaging (MRI), focusing on identifying the most common lesions and their distribution across various demographic factors. Materials and Methods: A cross-sectional analysis was conducted with 80 patients (aged 18-75 years) who presented with knee pain at an outpatient clinic. MRI scans were performed using a 1.5 Tesla MRI scanner, following a standardized protocol to assess articular cartilage, menisci, ligaments, bone marrow, synovium, joint capsule, and the patellofemoral joint. Lesions were categorized into degenerative, traumatic, inflammatory, and other types. Data analysis was performed using descriptive statistics and statistical tests to examine the relationships between lesion types, age, sex, and BMI. Results: The mean age of the cohort was 47.3 ± 13.1 years, with 57.5% males and 42.5% females. Degenerative lesions were the most common, present in 62.5% of patients, followed by traumatic lesions (26.25%), inflammatory lesions (7.5%), and other lesions (3.75%). Articular cartilage abnormalities were the most prevalent (58.75%), followed by meniscal lesions (35%) and ligament injuries (23.75%). The prevalence of degenerative lesions increased with age, while traumatic lesions were more common in younger individuals. Males had a higher incidence of both degenerative and traumatic lesions compared to females. The average pain duration was longest for degenerative lesions (7.1 ± 3.2 months) and shortest for inflammatory lesions (4.2 ± 1.8 months). Conclusion: MRI is a valuable diagnostic tool for assessing knee pain, revealing that degenerative lesions are the most common cause, particularly in middle-aged and older individuals. The findings emphasize the importance of considering patient demographics, such as age, sex, and BMI, in the diagnosis and management of knee pathologies. MRI plays a crucial role in guiding treatment strategies for patients with knee pain.