Background: Laryngoscopy and tracheal intubation commonly trigger a reflex sympathetic pressor response, resulting in elevated heart rate and blood pressure, which can be potentially hazardous in high-risk patients. This study aimed to compare the efficacy of esmolol versus labetalol in attenuating these hemodynamic changes during laryngoscopy and intubation in patients undergoing surgery under general anesthesia. Methods: A randomized study was conducted on 70 ASA I and II normotensive patients scheduled for elective surgical procedures, divided into two equal groups of 35 each. Group E received intravenous esmolol 1.0 mg/kg (diluted to 10 ml with 0.9% saline) 2 minutes before intubation, preceded by 10 ml normal saline at 5 minutes. Group L received intravenous labetalol 0.5 mg/kg (diluted to 10 ml) 5 minutes before intubation, followed by 10 ml normal saline at 2 minutes. All patients followed an identical anesthetic protocol. Hemodynamic parameters (heart rate, systolic blood pressure, diastolic blood pressure, and mean arterial pressure) were recorded at baseline, after induction, and at 1, 3, and 5 minutes post-intubation. Results; The esmolol group demonstrated significantly lower heart rates at 1, 3, and 5 minutes post-intubation compared to the labetalol group. However, the labetalol group showed significantly better control of systolic blood pressure, diastolic blood pressure, and mean arterial pressure at all measured time points post-intubation compared to the esmolol group. Conclusion: Labetalol (0.5 mg/kg) administered 5 minutes before laryngoscopy and intubation proved more effective than esmolol (1 mg/kg) in suppressing the overall hemodynamic stress response to laryngoscopy and intubation.