Introduction: The occurrence of epiphora is a common clinical manifestation of nasolacrimal duct occlusion. Stasis can also result in recurrent infection, with the most likely location being the intersection of the nasolacrimal duct and the lacrimal sac. Aims: To assess Mitomycin-C's safety and efficacy as a supplement to endoscopic dacryocystorhinostomy (DCR) with lacrimal sac stenting, particularly in terms of enhancing surgical results and avoiding nasolacrimal duct restenosis or scarring. Materials & Methods: The present study was a Prospective, Randomized Controlled Trial study. This Study was conducted for two years at Medica Superspecialty Hospital Kolkata. Total 50 patients were included in this study. Result: All the patients presented with epiphora (100%). Ten patients presented with swelling at the medial canthus of the eye (41.67%). One patient presented with swelling at the puncta (4.17%). Two patients presented with nasal discharge (8.33%). One presented with visual disturbance, that is, ambylopia (4.17%). Conclusion: The success of endoscopic dacryocystorhinostomy (DCR) with lacrimal sac stenting is significantly improved by mitomycin-C, we concluded. By preventing fibroblast proliferation and scar tissue formation, two primary reasons of DCR failure, its use helps lower the incidence of post-surgical stenosis and restenosis.