SSIs are infections of the tissues, organs, or spaces exposed by surgeons during performance of an invasive procedure. SSIs are classified into incisional and organ/space infections, and the former are further sub classified into superficial (limited to skin and subcutaneous tissue) and deep incisional categories. The patients were divided into two groups: Group A: Prophylaxis by systemic (intravenous) infiltration of the antibiotic. Group B: Prophylaxis by both systemic (intravenous) and intra-incisional infiltration of the antibiotic. The first patient was allocated to group A. The second patient to group B, the third one to group A and so on so forth till we achieved our desired number of subjects in both the groups. In Group 1, growth was seen in 7 patients. 1 (1.7%) patient had E. coli, 1 (1.7%) patient had pseudomonas and 5 (8.3%) patients had staphylococcus MRSA. In Group 2, only 1 (1.7%) patient had staphylococcus MRSA growth. In Group 2 majority of the patients did not have any growth on culture. Larger proportion of patients in Group 1 showed growth of organism in comparison to the Group 2, which was statistically significant (p<0.05).