Background:Laparoscopic cholecystectomy has revolutionized the gall bladder surgery as a day care procedure but for post-operative pain. This study compared the efficacy of Dexmedetomidine (1 μg/kg) and Fentanyl (1 μg/kg) as intraperitoneal adjuvant to 0.375% ropivacaine (40ml) given perioperatively for post-operative pain management in patients undergoing laparoscopic cholecystectomy surgeries under general anaesthesia. Materials & Methods:A total of 110 patients fulfilling the eligibility criteria were enrolled in the study and were randomized either to receive combination of ropivacaine with fentanyl (Group RF; n=55; mean age 39.02 years; 94.5% females) or combination of ropivacaine with Dexmedetomidine (Group RD; n=55; mean age 38.75 years; 90.9% females) respectively. Post-operative vital parameters (heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure and oxygen saturation) were noted. Sedation scores were measured using Ramsay Sedation Score. All the patients were followed up till 24 hours at every 2 hourly interval for pain (measured using Numeric Rating Scale), dose and amount of rescue analgesia (Diclofenac). Adverse effects, if any were noted. Results:Average NRS scores over 24 hours were significantly lower in RF as compared to RD group. Amount of rescue analgesia, number of patients requiring rescue analgesia and number of dosages of rescue analgesia required were significantly higher in RD as compared to that in the RF group. Post-operative sedation scores were significantly higher in RD as compared to that in RF group. No adverse effect was noted in RF group whereas in RD group, there was 1 (1.8%) patient each experiencing fever and headache as the adverse effect. Conclusion: Findings of the study showed that though both the combinations were safe to use, however, combination of fentanyl with ropivacaine provided far better analgesic effect without causing much sedation as compared to combination of dexmedetomidine with ropivacaine.