Background:AUB (abnormal uterine bleeding) is a common condition seen by Gynecologists. Existing literature data has reported that abnormal uterine bleeding can be attributed to changes in the expression of PR (progesterone receptors) and ER (estrogen receptors) in the endometriumwhich plays a vital role in abnormal bleeding etiology. Aim: The present study aimed to study the histopathological results of endometrium and estrogen and progesterone expression in the endometrium of subjects with AUB. Methods: The present study assessed 126 subjects, using endometrial biopsies done within the defined study period. Following histopathological assessment, all the subjects underwent immunohistochemistry assessment for progesterone receptor and estrogen receptor scoring utilizing the Allred scoring system. The data gathered were analyzed statistically. Results: The study results showed that heavy menstrual bleeding was reported in subjects aged 41-50 years. The majority of subjects had EH (endometrial hyperplasia) without atypia seen in 63% of subjects followed by proliferative endometrium, disordered proliferative endometrium, and secretory endometrium in 21%, 11%, and 5% of subjects respectively. In AUB subjects, mean Allred scores for ER expression in gland and stroma were significantly higher compared to scores for progesterone receptor expression with 6.0±1.1 versus 5.6±1.4 for stroma with p=0.00 and 7.1±1.3 versus 6.5±1.6 for glands with p=0.00. ER expression in the stroma and endometrial glands for various histological patterns of AUB was significantly higher compared to PR in EH without atypia with 6.0±1.14 versus 5.5±1.6 and p=0.001 for stroma and 7.0±1.6 versus 6.4±1.8 and p=0.001 for gland. For other histological patterns, ER expression was higher compared to PR expression, due to smaller cases, a test of significance was not applied. Conclusion: The present study concludes that an increase in ER expression is evident compared to PR expression in all histological patterns for subjects with abnormal uterine bleeding. ER expression was significantly higher in subjects with endometrial hyperplasia without atypia, suggesting that they might have a role in the etiopathogenesis of endometrial hyperplasia.