Background: COVID-19 has led to significant changes in dental practice. To break the chain of infection, several measures are being taken to focus on the transmission mode. Aims: This study investigated the changes in clinical practices amongst dental professionals during the COVID-19 pandemic. Methods and Material: A closed online survey was conducted among 202 dentists (academicians/practising dentists) selected using systematic random sampling. A 29-item closed-ended, pretested and validated questionnaire was used to assess the changes in clinical practice and compliance with their new protocols. The questionnaire included questions related to changes in personal hygiene, preventive and treatment procedures and personal protective equipment. The data was analysed using SPSS 21 (Statistical Package for Social Sciences) for descriptive and inferential statistics. A p-value of <0.05 was considered statistically significant. Results: 92%, 65%, and 41.6% reported changes in hand hygiene, use of personal protective equipment (PPE), and reduction in the use of air rotor and ultrasonic scalers respectively. Few dentists had provision for separate donning, and doffing areas (26%), elbow-operated taps (12%), micromotor (21%), and anti-retraction handpieces (15.8%). Conclusions: The findings revealed a substantial improvement in clinical practices irrespective of gender, qualification, experience, and type of practice.