Background: Varicose veins are a prevalent venous disorder affecting up to 40% of the population. Conventional surgical treatments are associated with notable complications and recovery time. Endovenous radio-frequency ablation (RFA) has emerged as a minimally invasive alternative offering faster recovery and reduced morbidity. Objective: To evaluate the effectiveness and safety of RFA in managing primary varicose veins in terms of symptom resolution, quality of life (QoL) improvement, and postoperative complications. Methods: A prospective study was conducted on 27 patients (42 limbs) with CEAP C2–C6 primary varicose veins involving the great saphenous vein (GSV). Preoperative and postoperative evaluations were done using duplex ultrasound, revised Venous Clinical Severity Score (rVCSS), and Aberdeen Varicose Vein Questionnaire (AVVQ). Follow-up assessments were performed at 24 hours, 1 week, 1 month, and 3 months. Data were analyzed using ANOVA, with significance set at P < 0.05. Results: The mean rVCSS significantly improved from 9.67 preoperatively to 4.28 at 3 months (P < 0.0001), and the mean AVVQ score decreased from 57.78 to 21.46 (P < 0.0001). GSV occlusion rate was 96.3% at 3 months, with only one case (3.7%) of recanalization. Minor complications included pain (37%), bruising (14.8%), paresthesia (7.4%), and thrombophlebitis (3.7%), with no cases of DVT, nerve injury, or infection. One case (3.7%) of skin burn was reported. Conclusion: Radio-frequency ablation is a safe, effective, and well-tolerated modality for the management of primary varicose veins. It offers significant improvement in QoL and clinical outcomes with minimal complications and early return to daily activities.