Background: Plantar fasciitis is a common cause of heel pain, often treated with corticosteroid injections; however, platelet-rich plasma (PRP) therapy has emerged as a promising alternative due to its potential to promote tissue healing. This study aimed to compare the efficacy and safety of PRP versus corticosteroid injections in the management of plantar fasciitis. Methods: In this prospective randomized controlled trial, 60 patients with chronic plantar fasciitis were allocated to receive either a single ultrasound-guided PRP injection (n=30) or corticosteroid injection (n=30). Pain and functional outcomes were assessed using the Visual Analog Scale (VAS) and Foot Function Index (FFI) at baseline, 4, 12, and 24 weeks post-injection. Results: Both groups showed significant improvement in pain and function over time. The corticosteroid group demonstrated faster pain relief at 4 weeks, while the PRP group exhibited significantly greater pain reduction and functional improvement at 12 and 24 weeks (p < 0.05). No major adverse effects were reported in either group. Conclusion: While corticosteroid injections provide quicker short-term pain relief, PRP injections offer superior long-term benefits in pain reduction and functional recovery in plantar fasciitis. PRP may be considered a safer and more effective option for sustained management of this condition.